Water-soluble Phytoconstituent molecules (mainly polyphenolic) can be converted into lipid-compatible molecular complexes. Several studies have indicated the beneficial role of phospholipids in enhancing the therapeutic efficacy of some molecules having poor oral absorption. Silybin is one such molecule having poor oral bioavailability. Efforts have been given to prepare phospholipids complex of silybin and to increase its oral bioavailability, therefore, therapeutic efficacy.Eclipta alba (L.) Hassk. (syn. Eclipta prostrata L.), is a plant belonging to the family Asteraceae. It grows commonly in moist places as a weed all over the world. It is widely distributed throughout India, China, Thailand, and Brazil. E. alba is widely used in India as a cholagogne and deobstruent in hepatic enlargement, for jaundice and other ailments of the liver and gall bladder.