Aortic stenosis (AS) has become the most frequent valve disease and has extensively been studied in recent years. Although gender differences have gained increasing attention in cardiolgy, little is known about gender differences in presentation and surgical outcome of AS so far.In 408 consecutive pts. referred to surgery because of symptomatic AS baseline clinical and echocardiographic data as well as outcome data were analyzed with regard to potential gender differences. At presentation, female pts. were significantly older (73.7 ± 9.3 vs. 66.5 ± 11.5 years; p<0,00001) and more symptomatic (NYHA class 2.3 ± 0.7 vs. 2.0 ± 0.7; p<0.0001). Overall survival as estimated by Kaplan Meier analysis tended to be slightly better in women (89.1%, 86.6%, 76.3% versus 92.8%, 89.8%, 81.4% at 1-, 2- and 5 years) but this difference did not reach statistical significance (p=0.3). Further research must address whether differences in baseline characteristics are due to differences in disease onset and progression or whether female patients get delayed medical attention for some reasons.