The national question, interethnic relations and ethnodemographic development of population were brought into focus of interest of scientific as well as the general public in the late 20th and early 21st century. The changes in ethnic structure determined by demographic, political, historical, geographical and numerous other factors are delicate questions and have crucial significance for the stability and development of Serbia. In that period (1991-2011) relevant changes happened in the ethnic structure of Serbia were primarily conditioned by differentiated natural growth per nationalities, migrations, as well as by changed declaration on national affiliation. At the same time, ethnocentric migrations (voluntary and forced) primarily influenced on the change of ethnic picture of Serbia in the sense of creating nationally more homogeneous state. But, it would be difficult to foresee the changes which will take place in the next period, mainly because of the open issues to do with the direction and scale of future migrations, stability of the national declaration and the general socio-economic and political climate in the country.