New applications and clinical trials in medicine, psychiatry, neuroscience and technology are changing our lives. The delicate border between clinical trials and conventional diagnostic / treatment methods is becoming more evident. At this delicate border, while current debate is continuing about novel research techniques, new ethical questions arise, that need both rational and humanistic answers and that affect mankind's understanding of self. Ethics is the essence of Medicine and Ethical requirements would diminish the scientific burden on human subjects. 'Mis-Un-True informed consent' is my new terminology for the informed consent process in clinical trials. The terminology does not aim to criticize any process but to enlighten the realities, conditions and values relevant to the process. Truth is always a friendly guide to choices, ethical processes and medical applications. This should be especially useful to professionals in Medicine and Research field, in ethics committees and for medical students.