Garlic (Allium sativum L., Liliaceae) is a nature's boon to mankind which has played an important dietary and therapeutic medicinal role throughout the history of mankind. Aluminum is a potent neurotoxin and has been associated with Alzheimer's disease causality for decades. Study demonstrated the ameliorative effect of garlic extract against aluminium-induced toxicity in rat model. Results reveal dose dependent response with the administration of therapeutic agent. Treatment with extract of Garlic revealed that it was significantly effective in recouping most of the biochemical alterations produced by the toxicant. Markers of liver injury and oxidative stress i.e. AST, ALT, ALAD,LPO and GSH showed significant recoupment with the therapy. Curative treatment with therapeutic agent prevented the leakage of AST, and ALT indicating stabilization of plasma membrane as well as repair of hepatic, renal and cerebral tissues damage.