Fibro-osseous lesions (FOLs) of the craniofacial bones comprise a diverse group of pathologic conditions that includes developmental lesions, reactive or dysplastic diseases, and neoplasms. They share many similar histopathologic features with other non -fibro-osseous disease processes that develop within the jawbones. Thus a definitive diagnosis of fibro-osseous lesions (FOLs) requires a correlation of the histological features with the clinical, radiographic, and intra-operative findings. This book highlights the importance of the role of Multi-detector row CT images, in assessment of fibro-osseous lesions of craniofacial complex in patients with known fibro-osseous lesions,facial disfigurement ,and facial swelling . MDCT including reformations better delineate craniofacial complex anatomy than do single-detector row CT images. It becomes possible to depict the complete path of complex structures. It is confirmed to be valuable in the diagnosis and in guiding the surgical interventions by allowing pre-operative delineation of craniofacial complex anatomy. MDCT is a powerful diagnostic and illustrative tool that will narrow the gap between the radiologists and the surgeons.