Information Technology and banking performance is one of the most exciting areas of research that has been the focus of intense interest throughout the globe over the decades, but little has been devoted to examine the impact of IT on the profitability of African banks, specially in sub Sahara countries. This empirical study examines the impact of IT investment on the profitability of Ethiopia banking sector along with other bank specific profit determinants. It should be known that In Ethiopian banking sector the context for making IT investment decisions has been altered in the recent years. Currently modern banking services such as ATM services, Mobile banking, Internet and SMS banking are increasingly becoming available. With respect to profitability, Ethiopian banking is booming. Financial results for the 2010 fiscal year show an industry enjoying high growth, high profits, and high dividends. Their profits were up 45 percent and shareholders (at banks open for more than a year) received an average return of 27 percent on their investments.